Meta-analysis of 16 studies of the association of alcohol with colorectal cancer

S McNabb; TA Harrison; D Albanes; SI Berndt; H Brenner; BJ Caan; PT Campbell; Y Cao; J Chang-Claude; A Chan; Z Chen; DR English; GG Giles; EL Giovannucci; PJ Goodman; RB Hayes; M Hoffmeister; EJ Jacobs; AD Joshi; SC Larsson; L Le Marchand; L Li; Y Lin; S Männistö; RL Milne; H Nan; CC Newton; S Ogino; PS Parfrey; PS Petersen; JD Potter; RE Schoen; ML Slattery; YR Su; CM Tangen; TC Tucker; SJ Weinstein; E White; A Wolk; MO Woods; AI Phipps; U Peters

Journal article

Meta-analysis of 16 studies of the association of alcohol with colorectal cancer

S McNabb, TA Harrison, D Albanes, SI Berndt, H Brenner, BJ Caan, PT Campbell, Y Cao, J Chang-Claude, A Chan, Z Chen, DR English, GG Giles, EL Giovannucci, PJ Goodman, RB Hayes, M Hoffmeister, EJ Jacobs, AD Joshi, SC Larsson Show all

International Journal of Cancer | WILEY | Published : 2020

DOI: 10.1002/ijc.32377

Abstract

Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a combined analysis of 16 studies of CRC to examine the shape of the alcohol–CRC association, investigate potential effect modifiers of the association, and examine differential effects of alcohol consumption by cancer anatomic site and stage. We collected information on alcohol consumption for 14,276 CRC cases and 15,802 controls from 5 case-control and 11 nested case-control studies of CRC. We compared adjusted logistic regression models ..

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University of Melbourne Researchers

Dallas English Author

Graham Giles Author

Roger Milne Author

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Grants

Awarded by Cancer Council Victoria

Funding Acknowledgements

Grant sponsor: Australian National Health and Medical Research Council; Grant numbers: 1074383, 396414; Grant sponsor: Canadian Institutes of Health Research; Grant number: CRT 43821; Grant sponsor: Cancer Council Victoria; Grant sponsor: Damon Runyon Cancer Research Foundation; Grant number: CI-8; Grant sponsor: Division of Cancer Prevention, National Cancer Institute; Grant sponsor: German Federal Ministry of Education and Research; Grant numbers: 01ER0814, 01GL1712, 01KH0404; Grant sponsor: German Research Council; Grant numbers: BR 1704/6-4, BR 1704/6-1, BR 1704/6-3, BR 1704/6-6, CH 117/1-1; Grant sponsor: Karolinska Institutet; Grant number: Distinguished Professor Award; Grant sponsor: National Cancer Institute; Grant numbers: 5UM1CA182883, HHSN261201500005C, R01 CA059045, R01 CA120582, R01CA136726, RFA #CA-09-002 U19 CA148107, U01 CA137088, U10CA37429; Grant sponsor: National Cancer Institute of Canada; Grant numbers: 18223, 18226; Grant sponsor: National Heart, Lung, and Blood Institute; Grant numbers: HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN268201100046C, HHSN271201100004C; Grant sponsor: National Institutes of Health; Grant numbers: K07 CA190673, P01 CA055075, P01 CA087969, P50 CA127003, R01 CA137178, R01 CA151993, R01 CA48998, R01 CA60987, R35 CA197735, U01 CA164973, U01 CA167552, U01 CA74783, UM1 CA167552, UM1 CA186107; Grant sponsor: Swedish Cancer Foundation; Grant sponsor: Swedish Research Council/Infrastructure Grant; Grant sponsor: Victorian Health Promotion Foundation